Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Cyclohexylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL8041569 | 0.89 | EPHX1 (0.43) | POLBRAB9AEPHX1GALR3EPHX2 | |
| Cyclohexylamine SCHEMBL8041572 | 0.89 | EPHX1 (0.43) | POLBRAB9AEPHX1GALR3EPHX2 | |
| Cyclohexylamine SCHEMBL8041263 | 0.88 | EPHX1 (0.38) | POLBRAB9AEPHX1CCR2PTGDR2 | |
| Cyclohexylamine SCHEMBL8025513 | 0.85 | DPEP1 (0.43) | ALDH1A1PTGDR2 | |
| Lysine SCHEMBL8035651 | 0.84 | EPHX1 (0.40) | POLBRAB9AEPHX1GALR3EPHX2 | |
| Lysine SCHEMBL8035654 | 0.84 | EPHX1 (0.40) | POLBRAB9AEPHX1GALR3EPHX2 | |
| Cyclohexylamine SCHEMBL7792713 | 0.84 | TP53 (0.44) | RAB9APTGDR2MAOB | |
| 3-Hydroxybenzaldehyde SCHEMBL7798346 | 0.83 | POLB (0.41) | POLBMAOB | |
| Benzaldehyde SCHEMBL7798223 | 0.82 | ALDH1A1 (0.44) | RAB9AEPHX2ALDH1A1PTGDR2 | |
| Cyclohexylamine SCHEMBL7798152 | 0.81 | ALDH1A1 (0.51) | POLBALDH1A1PTGDR2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |