Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Cyclohexylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPEP1 | P16444 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL8041263 | 0.87 | EPHX1 (0.38) | DPEP1PTGDR2 | |
| Cyclohexylamine SCHEMBL8039213 | 0.87 | GRIK1 (0.45) | DPEP1PTGDR2CYP1A2XBP1MCHR1 | |
| Cyclohexylamine SCHEMBL8039210 | 0.87 | GRIK1 (0.45) | DPEP1PTGDR2CYP1A2XBP1MCHR1 | |
| Glycine SCHEMBL8217169 | 0.86 | CYP1A2 (0.49) | CYP1A2GRIK1GRIK2HDAC3ADAM17 | |
| Cyclohexylamine SCHEMBL8035100 | 0.85 | POLB (0.42) | PTGDR2ALDH1A1 | |
| Cyclohexylamine SCHEMBL7792125 | 0.85 | CACNA1B (0.41) | DPEP1PTGDR2HSD11B1KCNH2ALDH1A1 | |
| 4-Hydroxybenzaldehyde SCHEMBL7798048 | 0.83 | ALDH5A1 (0.47) | ALDH1A1 | |
| Benzaldehyde SCHEMBL7798223 | 0.83 | ALDH1A1 (0.44) | PTGDR2ALDH1A1 | |
| Cyclohexylamine SCHEMBL7802678 | 0.82 | CYP1A2 (0.42) | DPEP1PTGDR2CYP1A2HDAC3HDAC1 | |
| Cyclohexylamine SCHEMBL7801490 | 0.82 | ALDH1A1 (0.54) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |