Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050392 | 0.88 | EP300 (0.44) | KEAP1EP300NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8033095 | 0.84 | ALDH1A1 (0.52) | KEAP1EP300NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8052220 | 0.83 | ALDH1A1 (0.54) | EP300ALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL8042219 | 0.82 | PTGS2 (0.44) | ALDH1A1SMN1; SMN2LMNATP53MAPT | |
| SCHEMBL8715704 | 0.82 | EP300 (0.40) | KEAP1EP300NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8032354 | 0.81 | ALDH1A1 (0.46) | KEAP1EP300NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8033844 | 0.81 | EP300 (0.42) | KEAP1EP300NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8034180 | 0.80 | MAPT (0.49) | KEAP1EP300NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8045773 | 0.80 | EP300 (0.45) | KEAP1EP300NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8034578 | 0.80 | EP300 (0.46) | KEAP1EP300NFE2L2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |