Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 5/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA4 | P22748 | 5/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 4/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049857 | 0.87 | EP300 (0.44) | EP300KEAP1NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8044600 | 0.87 | EP300 (0.46) | EP300KEAP1NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8033042 | 0.86 | MAPT (0.46) | EP300KEAP1NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8043646 | 0.83 | ALDH1A1 (0.54) | EP300ALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL8046892 | 0.83 | EP300 (0.43) | EP300KEAP1NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8032741 | 0.82 | PTGS2 (0.48) | ALDH1A1SMN1; SMN2LMNATP53CA1 | |
| SCHEMBL8034578 | 0.82 | EP300 (0.46) | EP300KEAP1NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8033844 | 0.81 | EP300 (0.42) | EP300KEAP1NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8033095 | 0.80 | ALDH1A1 (0.52) | EP300KEAP1NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8041878 | 0.80 | KEAP1 (0.45) | EP300KEAP1NFE2L2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |