Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 12/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 10/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.38 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27559346 | 0.85 | SLC9A1 (0.40) | SLC9A1MTNR1BMTNR1APARP1SLC9A5 | |
| SCHEMBL496918 | 0.80 | SLC9A1 (0.43) | SLC9A1MTNR1BMTNR1APARP1SLC9A5 | |
| SCHEMBL7122066 | 0.78 | PARP1 (0.57) | SLC9A1MTNR1BMTNR1APARP1SLC9A5 | |
| SCHEMBL583934 | 0.78 | MTNR1B (0.45) | SLC9A1MTNR1BMTNR1APARP1SLC9A5 | |
| SCHEMBL30184316 | 0.78 | PARP1 (0.57) | SLC9A1MTNR1BMTNR1APARP1SLC9A5 | |
| SCHEMBL28775369 | 0.77 | ALDH1A1 (0.46) | MTNR1BMTNR1AKDM4E | |
| SCHEMBL28816930 | 0.77 | SLC9A1 (0.39) | SLC9A1MTNR1BMTNR1APARP1SLC9A5 | |
| SCHEMBL30884588 | 0.77 | ALDH1A1 (0.46) | MTNR1BMTNR1AKDM4E | |
| SCHEMBL7781199 | 0.77 | MTNR1A (0.44) | SLC9A1MTNR1BMTNR1ASLC9A5SLC9A2 | |
| SCHEMBL10005787 | 0.75 | MTNR1B (0.39) | SLC9A1MTNR1BMTNR1APARP1SLC9A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011528012-A | — | — | 2011-11-10 | — | — | JP | claimed |
| EP-2328882-A1 | SYNTHESIS OF 6,7-DIHYDRO-1H-INDENO[5,4-B]FURAN-8(2H)-ONE AS INTERMEDIATE IN THE PREPARATION OF RAMELTEON | LEK Pharmaceuticals d.d. (SI) | 2011-06-08 | — | — | EP | claimed |
| WO-2010007022-A1 | SYNTHESIS OF 6,7-DIHYDRO-1H-INDENO[5,4-B]FURAN-8(2H)-ONE AS INTERMEDIATE IN THE PREPARATION OF RAMELTEON | LEK PHARMACEUTICALS D.D. (SI) | 2010-01-21 | — | — | WO | claimed |
| US-20120071673-A1 | SYNTHESIS OF (S)-N-[2-(1,6,7,8-TETRAHYDRO-2H-INDENO-[5,4-B]FURAN-8-YL)ETHYL]PROPIONAMIDE | LEK PHARMACEUTICALS D.D. (SI) | 2012-03-22 | — | — | US | disclosed |
| US-20120071673-A1 | SYNTHESIS OF (S)-N-[2-(1,6,7,8-TETRAHYDRO-2H-INDENO-[5,4-B]FURAN-8-YL)ETHYL]PROPIONAMIDE | LEK PHARMACEUTICALS D.D. (SI) | 2012-03-22 | — | — | US | disclosed |
| US-20110184058-A1 | SYNTHESIS OF 6,7-DIHYDRO-1H-INDENO[5, 4-B] FURAN-8(2H)-ONE AS INTERMEDIATE IN THE PREPARATION OF REMELTEON | LEK PHARMACEUTICALS D.D. (SI) | 2011-07-28 | — | — | US | disclosed |
| US-20110184058-A1 | SYNTHESIS OF 6,7-DIHYDRO-1H-INDENO[5, 4-B] FURAN-8(2H)-ONE AS INTERMEDIATE IN THE PREPARATION OF REMELTEON | LEK PHARMACEUTICALS D.D. (SI) | 2011-07-28 | — | — | US | disclosed |
| US-20110184058-A1 | SYNTHESIS OF 6,7-DIHYDRO-1H-INDENO[5, 4-B] FURAN-8(2H)-ONE AS INTERMEDIATE IN THE PREPARATION OF REMELTEON | LEK PHARMACEUTICALS D.D. (SI) | 2011-07-28 | — | — | US | disclosed |
| EP-2328882-A1 | SYNTHESIS OF 6,7-DIHYDRO-1H-INDENO[5,4-B]FURAN-8(2H)-ONE AS INTERMEDIATE IN THE PREPARATION OF RAMELTEON | LEK Pharmaceuticals d.d. (SI) | 2011-06-08 | — | — | EP | disclosed |
| EP-2243775-A1 | Synthesis of 1-(2,3-Dihydrobenzofuran-4-YL)ethanone as intermediate in the preparation of ramelteon | LEK Pharmaceuticals d.d. (SI) | 2010-10-27 | — | — | EP | disclosed |
| WO-2010115897-A2 | SYNTHESIS OF 1-(2,3-DIHYDROBENZOFURAN-4-YL)ETHANONE AS INTERMEDIATE IN THE PREPARATION OF RAMELTEON | LEK PHARMACEUTICALS D.D. (SI) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010092107-A1 | SYNTHESIS OF (S)-N-[2-(1,6,7,8-TETRAHYDRO-2H-INDENO-[5,4-B]FURAN-8-YL)ETHYL]PROPIONAMIDE | LEK PHARMACEUTICALS D.D. (SI) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010007022-A1 | SYNTHESIS OF 6,7-DIHYDRO-1H-INDENO[5,4-B]FURAN-8(2H)-ONE AS INTERMEDIATE IN THE PREPARATION OF RAMELTEON | LEK PHARMACEUTICALS D.D. (SI) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010007022-A1 | SYNTHESIS OF 6,7-DIHYDRO-1H-INDENO[5,4-B]FURAN-8(2H)-ONE AS INTERMEDIATE IN THE PREPARATION OF RAMELTEON | LEK PHARMACEUTICALS D.D. (SI) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184058-A1 | SYNTHESIS OF 6,7-DIHYDRO-1H-INDENO[5, 4-B] FURAN-8(2H)-ONE AS INTERMEDIATE IN THE PREPARATION OF REMELTEON | CYP2B6, CYP2D6, CYP2J2 | SLC9A1 4400/4885MTNR1B 90/4885MTNR1A 153/4885 |
| US-20120071673-A1 | SYNTHESIS OF (S)-N-[2-(1,6,7,8-TETRAHYDRO-2H-INDENO-[5,4-B]FURAN-8-YL)ETHYL]PROPIONAMIDE | CYP2B6, CYP2D6, CYP2A6 | SLC9A1 4090/4885MTNR1B 790/4885MTNR1A 1049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.