Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664936 | 0.82 | LMNA (0.58) | LMNASMN1; SMN2POLBGAACHRM1 | |
| SCHEMBL337723 | 0.80 | GNAI3 (0.52) | POLBKMT2ATDP1ALDH1A1NPC1 | |
| SCHEMBL12615399 | 0.80 | MAPT (0.59) | LMNASMN1; SMN2POLBGAACHRM1 | |
| SCHEMBL16102147 | 0.80 | GAA (0.56) | LMNASMN1; SMN2POLBGAACHRM1 | |
| SCHEMBL27997797 | 0.78 | GAA (0.59) | LMNASMN1; SMN2POLBGAACHRM1 | |
| SCHEMBL16049958 | 0.78 | L3MBTL1 (0.41) | LMNASMN1; SMN2POLBRAB9A | |
| SCHEMBL7096747 | 0.77 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2POLBGAACHRM1 | |
| SCHEMBL355693 | 0.77 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2POLBGAACHRM1 | |
| SCHEMBL5494939 | 0.76 | HPGD (0.52) | KMT2AMAPTNPC1RAB9A | |
| SCHEMBL5823241 | 0.76 | GAA (0.73) | LMNASMN1; SMN2POLBGAACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |