Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048020 | 0.82 | HCAR2 (0.56) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8050918 | 0.78 | MAPK8 (0.55) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8050209 | 0.77 | RXRA (0.43) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8047234 | 0.77 | RXRA (0.43) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8042630 | 0.76 | RAB9A (0.35) | USP7RAB9AALDH1A1NPC1MAPK8 | |
| SCHEMBL8051764 | 0.75 | RXRA (0.41) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8044684 | 0.75 | RXRA (0.42) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL4282035 | 0.74 | HCAR2 (0.57) | RXRARXRBRXRGHCAR2ALDH1A1 | |
| SCHEMBL8050241 | 0.74 | CA1 (0.35) | ALDH1A1MAPK8MAPK9MEN1KMT2A | |
| SCHEMBL8042939 | 0.74 | RXRA (0.41) | RXRARXRBRXRGHCAR2USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |