Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044684 | 0.89 | RXRA (0.42) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8046385 | 0.88 | RXRA (0.41) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8051764 | 0.87 | RXRA (0.41) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8042939 | 0.86 | RXRA (0.41) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8044327 | 0.85 | RXRA (0.41) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8044736 | 0.84 | RXRA (0.40) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8044449 | 0.83 | SMN1; SMN2 (0.43) | RXRARXRBRXRGHCAR2ALDH1A1 | |
| SCHEMBL8043440 | 0.83 | F2 (0.43) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8043212 | 0.83 | RXRA (0.39) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8048020 | 0.82 | HCAR2 (0.56) | RXRARXRBRXRGHCAR2USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |