Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046385 | 0.93 | RXRA (0.41) | RXRARXRBRXRGHCAR2MAPK8 | |
| SCHEMBL8050209 | 0.89 | RXRA (0.43) | RXRARXRBRXRGHCAR2MAPK8 | |
| SCHEMBL8044736 | 0.88 | RXRA (0.40) | RXRARXRBRXRGHCAR2MAPK8 | |
| SCHEMBL8043212 | 0.86 | RXRA (0.39) | RXRARXRBRXRGHCAR2MAPK8 | |
| SCHEMBL8051764 | 0.85 | RXRA (0.41) | RXRARXRBRXRGHCAR2MAPK8 | |
| SCHEMBL8044854 | 0.84 | RXRA (0.39) | RXRARXRBRXRGHCAR2ALDH1A1 | |
| SCHEMBL8042939 | 0.83 | RXRA (0.41) | RXRARXRBRXRGHCAR2MAPK8 | |
| SCHEMBL8032493 | 0.83 | RAB9A (0.44) | ALDH1A1RAB9AKDM4EKMT2APOLB | |
| SCHEMBL8044327 | 0.83 | RXRA (0.41) | RXRARXRBRXRGHCAR2MAPK8 | |
| SCHEMBL8044449 | 0.81 | SMN1; SMN2 (0.43) | RXRARXRBRXRGHCAR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |