Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | IRS1 | P35568 | 1/20 | 0.38 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051075 | 0.89 | ALDH1A1 (0.35) | SMN1; SMN2POLBHSD17B10MAPTALDH1A1 | |
| SCHEMBL8043583 | 0.84 | AKT1 (0.33) | GAAAKT1IRS1GAB1 | |
| SCHEMBL8043647 | 0.83 | F2 (0.40) | ALDH1A1RAB9A | |
| SCHEMBL8042807 | 0.82 | MEN1 (0.44) | SMN1; SMN2POLBUSP2HSD17B10MEN1 | |
| SCHEMBL8043817 | 0.81 | MAPK8 (0.37) | MEN1KMT2AMAPTALDH1A1AKT1 | |
| SCHEMBL8044449 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2POLBUSP2HSD17B10MEN1 | |
| SCHEMBL8042354 | 0.80 | MAPK8 (0.34) | — | |
| SCHEMBL8033917 | 0.79 | MAPK8 (0.56) | SMN1; SMN2POLBUSP2HSD17B10MEN1 | |
| SCHEMBL8041884 | 0.78 | MAPK8 (0.36) | ALDH1A1TSHRRAB9A | |
| SCHEMBL8044039 | 0.78 | ALDH1A1 (0.37) | SMN1; SMN2POLBHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |