Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044854 | 0.88 | RXRA (0.39) | SMN1; SMN2HSD17B10USP2POLBRXRA | |
| SCHEMBL8042807 | 0.84 | MEN1 (0.44) | SMN1; SMN2HSD17B10USP2POLBRECQL | |
| SCHEMBL8042939 | 0.83 | RXRA (0.41) | RXRARXRBRXRGHCAR2GAA | |
| SCHEMBL8050209 | 0.83 | RXRA (0.43) | HSD17B10POLBRXRARXRBRXRG | |
| SCHEMBL8042764 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2HSD17B10USP2POLBRECQL | |
| SCHEMBL8044684 | 0.81 | RXRA (0.42) | POLBRXRARXRBRXRGRECQL | |
| SCHEMBL8043440 | 0.81 | F2 (0.43) | RXRARXRBRXRGALDH1A1HCAR2 | |
| SCHEMBL8033917 | 0.81 | MAPK8 (0.56) | SMN1; SMN2HSD17B10USP2POLBMEN1 | |
| SCHEMBL8044327 | 0.80 | RXRA (0.41) | SMN1; SMN2HSD17B10POLBRXRARXRB | |
| SCHEMBL8046385 | 0.80 | RXRA (0.41) | RXRARXRBRXRGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |