Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18199 | 0.97 | TSHR (0.45) | TSHRLMNAGRM2GRM3GRM4 | |
| Hydrochloric Acid SCHEMBL3997454 | 0.95 | TSHR (0.43) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL24337131 | 0.89 | TSHR (0.39) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL9893214 | 0.83 | TSHR (0.52) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL9893343 | 0.83 | TSHR (0.52) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL16577412 | 0.83 | TSHR (0.52) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL20827318 | 0.80 | ALDH1A1 (0.42) | TSHRLMNAGRM5ALDH1A1EPHX2 | |
| SCHEMBL16237715 | 0.79 | EPHX2 (0.36) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL2435778 | 0.78 | APLNR (0.46) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL2435779 | 0.78 | APLNR (0.46) | TSHRLMNAGRM2GRM3GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1065277-C | Process for production of avermectins and cultures therefor | PFIZER (US) | 2001-05-02 | — | — | CN | disclosed |
| US-6103504-A | STREPTOMYCES MUTANT LACKING BRANCHED-CHAIN AMINO ACID TRANSAMINASE ACTIVITY, BRANCHED-CHAIN OXO ACID BIOSYNTHETIC ACTIVITY AND LACKING AVERMECTIN B-O-METHYL TRANSFERASE ACTIVITY; FOR PRODUCTION OF PARASITIDES AND ANTHELMINTICS | PFIZER INC. (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0640142-B1 | PROCESS FOR PRODUCTION OF AVERMECTINS AND CULTURES THEREFOR | PFIZER (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5583015-A | CULTURING MUTANT STRAIN OF STREPTOMYCES AVERMITILIS LACKING BRANCHED CHAIN AMINO ACID TRANSAMINASE AND/OR 2-OXO ACID DEHYDROGENASE ACTIVITY UNDER AEROBIC CONDITIONS IN AQUEOUS NUTRIENT MEDIUM CONTAINING SPECIFIED ACID OR PRECURSOR | PFIZER INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-5583029-A | PARASITICIDES | PFIZER INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-5576199-A | CULTURE OF STREPTOMYCES UNDER AEROBIC CONDITIONS IN NUTRIENTS | PFIZER INC. (US) | 1996-11-19 | — | — | US | disclosed |
| US-5576200-A | CULTURING A MUTANT STRAIN OF STREPTOMYCES | PFIZER INC. (US) | 1996-11-19 | — | — | US | disclosed |
| US-5565359-A | STREPTOMYCES CULTURED UNDER AEROBIC CONDITIONS IN NUTRIENT MEDIA CONTAINING AN ACID | PFIZER INC. (US) | 1996-10-15 | — | — | US | disclosed |
| US-5525506-A | Process for production of avermectins and cultures therefor | PFIZER INC. (US) | 1996-06-11 | — | — | US | disclosed |
| EP-0640142-A1 | PROCESS FOR PRODUCTION OF AVERMECTINS AND CULTURES THEREFOR | PFIZER INC. (US) | 1995-03-01 | — | — | EP | disclosed |
| EP-0276131-B1 | NON-NATURAL DEMETHYLAVERMECTINS AND PROCESS THEREFOR | PFIZER INC. (US) | 1993-04-07 | — | — | EP | disclosed |
| EP-0316124-B1 | ETHYLATED AVERMECTINS | PFIZER INC. (US) | 1993-04-07 | — | — | EP | disclosed |
| US-5077278-A | Parasiticides | PFIZER INC. (US) | 1991-12-31 | — | — | US | disclosed |
| EP-0316124-A2 | Ethylated avermectins | PFIZER INC. (US) | 1989-05-17 | — | — | EP | disclosed |
| EP-0313297-A2 | Process for production of avermectin aglycones and cultures therefor | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |
| CN-88100649-A | Methods for producing avermectin B and cultures thereof | — | 1988-10-26 | — | — | CN | disclosed |
| EP-0284176-A2 | Process for production of avermectins and cultures therefor | PFIZER INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| CN-88100373-A | Avermectins and production method of culture bacteria thereof | — | 1988-08-31 | — | — | CN | disclosed |
| EP-0276103-A2 | Process for production of B avermectins and cultures therefor | PFIZER INC. (US) | 1988-07-27 | — | — | EP | disclosed |
| EP-0276131-A2 | Non-natural demethylavermectins and process therefor | PFIZER INC. (US) | 1988-07-27 | — | — | EP | disclosed |