SCHEMBL9893343

SCHEMBL9893343

O=C(O)C1CCC(F)(F)C1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.52
LMNA P02545 3/20 0.52
GRM2 Q14416 2/20 0.52
GRM3 Q14832 2/20 0.52
GRM4 Q14833 2/20 0.52
CYP2C19 P33261 2/20 0.52
CYP1A2 P05177 2/20 0.52
ALOX15 P16050 2/20 0.52
TDP1 Q9NUW8 1/20 0.52
GRM8 O00222 1/20 0.52
GRM6 O15303 1/20 0.52
GRM5 P41594 1/20 0.52
MTOR P42345 1/20 0.52
GRM1 Q13255 1/20 0.52
PLCB1 Q9NQ66 1/20 0.52
APLNR P35414 1/20 0.41
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
GABRP O00591 1/20 0.36
GABRD O14764 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16577412 1.00 TSHR (0.52) TSHRLMNAGRM2GRM3GRM4
SCHEMBL9893214 1.00 TSHR (0.52) TSHRLMNAGRM2GRM3GRM4
SCHEMBL4612651 0.86 TSHR (0.44) TSHRLMNAGRM2GRM3GRM4
SCHEMBL6371192 0.86 TSHR (0.44) TSHRLMNAGRM2GRM3GRM4
SCHEMBL18199 0.85 TSHR (0.45) TSHRLMNAGRM2GRM3GRM4
SCHEMBL34475817 0.85 GRM2 (0.42) TSHRLMNAGRM2GRM3GRM4
Lithium SCHEMBL8042771 0.83 TSHR (0.43) TSHRLMNAGRM2GRM3GRM4
Hydrochloric Acid SCHEMBL3997454 0.83 TSHR (0.43) TSHRLMNAGRM2GRM3GRM4
SCHEMBL27685559 0.83 GRM2 (0.34) TSHRLMNAGRM2GRM3GRM4
SCHEMBL20221354 0.81 GRM2 (0.33) TSHRLMNAGRM2GRM3GRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4188379-B1 POLYCYCLIC CAP-DEPENDENT ENDONUCLEASE INHIBITORS FOR TREATING OR PREVENTING INFLUENZA MERCK SHARP & DOHME LLC (US) 2026-02-25 EP disclosed
US-20250388604-A1 Compounds and Their Use as PDE4 Activators MIRONID LIMITED (GB) 2025-12-25 US disclosed
US-20250376482-A1 TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER HOFFMANN-LA ROCHE INC. (US) 2025-12-11 US disclosed
US-12466805-B2 Pharmaceutical compounds ALMAC DISCOVERY LIMITED (GB) 2025-11-11 US disclosed
US-20250313574-A1 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME EISAI R&D MANAGEMENT CO., LTD. (JP) 2025-10-09 US disclosed
US-20250223276-A1 Substituted Pyrrolidinyl And Piperidinyl Compounds And Related Methods Of Treatment JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2025-07-10 US disclosed
EP-4572762-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS Mironid Limited (GB) 2025-06-25 EP disclosed
US-12338248-B2 Aminopyrimidine derivatives as cyclin-dependent kinase inhibitors ACCUTAR BIOTECHNOLOGY INC. (US) 2025-06-24 US disclosed
WO-2025125666-A1 SUBSTITUTED IMIDAZOLES AS INHIBITORS OF NAV1.8 Grünenthal GmbH (DE) 2025-06-19 WO disclosed
EP-4568959-A1 BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2025-06-18 EP disclosed
WO-2013106520-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2013-07-18 WO disclosed
US-20130183269-A1 Hepatitis C Virus Inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2013-07-18 US disclosed
WO-2013106520-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2013-07-18 WO disclosed
US-20130183269-A1 Hepatitis C Virus Inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2013-07-18 US disclosed
EP-2582670-A1 PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2013-04-24 EP disclosed
US-20120149733-A1 PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY 2012-06-14 US disclosed
US-20120149733-A1 PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY 2012-06-14 US disclosed
US-20120149733-A1 PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY 2012-06-14 US disclosed
WO-2011159852-A1 PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2011-12-22 WO disclosed
WO-2011159852-A1 PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2011-12-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12466805-B2 Pharmaceutical compounds USP19, USP18, UBE2I TSHR 4512/4885LMNA 3830/4885GRM2 4605/4885
US-20250376482-A1 TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CCNI, TOP2B TSHR 1260/4885LMNA 974/4885GRM2 2773/4885
US-12338248-B2 Aminopyrimidine derivatives as cyclin-dependent kinase inhibitors CDK6, CDK2, CDK8 TSHR 4434/4885LMNA 2401/4885GRM2 2856/4885
US-20130183269-A1 Hepatitis C Virus Inhibitors HAVCR2, MAVS, EIF2AK2 TSHR 4427/4885LMNA 4392/4885GRM2 4675/4885
US-20250313574-A1 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME NEU1, NEU2, NEU4 TSHR 2456/4885LMNA 1117/4885GRM2 1120/4885
US-20250223276-A1 Substituted Pyrrolidinyl And Piperidinyl Compounds And Related Methods Of Treatment HCRTR2, HCRTR1, CNR2 TSHR 1953/4885LMNA 1405/4885GRM2 96/4885
US-20250388604-A1 Compounds and Their Use as PDE4 Activators PDE4A, PDE7A, PDE4B TSHR 1206/4885LMNA 471/4885GRM2 2295/4885
US-20120149733-A1 PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY CCR2, CCR5, CCL11 TSHR 1068/4885LMNA 4346/4885GRM2 1208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.