Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.52 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | GRM6 | O15303 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.52 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.52 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9893343 | 1.00 | TSHR (0.52) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL16577412 | 1.00 | TSHR (0.52) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL4612651 | 0.86 | TSHR (0.44) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL6371192 | 0.86 | TSHR (0.44) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL18199 | 0.85 | TSHR (0.45) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL34475817 | 0.85 | GRM2 (0.42) | TSHRLMNAGRM2GRM3GRM4 | |
| Lithium SCHEMBL8042771 | 0.83 | TSHR (0.43) | TSHRLMNAGRM2GRM3GRM4 | |
| Hydrochloric Acid SCHEMBL3997454 | 0.83 | TSHR (0.43) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL27685559 | 0.83 | GRM2 (0.34) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL20221354 | 0.81 | GRM2 (0.33) | TSHRLMNAGRM2GRM3GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825654-A | Phenylmethylene piperidine derivatives, preparation method, intermediates and uses thereof | 北京酷瓴生物技术有限公司 | 2020-10-27 | — | — | CN | disclosed |
| WO-2020211836-A1 | BENZENE PIPERIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF AND USE THEREOF | 北京酷瓴生物技术有限公司 | 2020-10-22 | — | — | WO | disclosed |
| EP-2582670-B1 | PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2015-12-16 | — | — | EP | disclosed |
| EP-2582670-B1 | PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2015-12-16 | — | — | EP | disclosed |
| CN-103068800-B | Piperidinyl compound as a modulator of chemokine receptor activity | BRISTOL-MYERS SQUIBB CO. (US) | 2014-10-29 | — | — | CN | disclosed |
| US-8642622-B2 | Piperidinyl compound as a modulator of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-02-04 | — | — | US | disclosed |
| US-8642622-B2 | Piperidinyl compound as a modulator of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-02-04 | — | — | US | disclosed |
| EP-2582670-A1 | PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2013-04-24 | — | — | EP | disclosed |
| CN-103068800-A | Piperidinyl compound as a modulator of chemokine receptor activity | BRISTOL MYERS SQUIBB CO | 2013-04-24 | — | — | CN | disclosed |
| US-20120149733-A1 | PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY | 2012-06-14 | — | — | US | disclosed |
| WO-2011159852-A1 | PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149733-A1 | PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY | CCR2, CCR5, CCL11 | TSHR 1068/4885LMNA 4346/4885GRM2 1208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.