Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042054 | 0.81 | ALDH1A1 (0.43) | NPC1RAB9APKM | |
| SCHEMBL8048790 | 0.79 | RAB9A (0.44) | NPC1RAB9ASMN1; SMN2TDP1HTR7 | |
| SCHEMBL8048729 | 0.77 | ELANE (0.47) | NPC1RAB9ASMN1; SMN2FBP1TDP1 | |
| SCHEMBL8050908 | 0.76 | ELANE (0.31) | — | |
| SCHEMBL8046787 | 0.76 | ALDH1A1 (0.42) | SMN1; SMN2TDP1PKM | |
| SCHEMBL8042803 | 0.75 | MAPK8 (0.46) | NPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL8044613 | 0.75 | ALDH1A1 (0.38) | SMN1; SMN2 | |
| SCHEMBL8050943 | 0.73 | FBP1 (0.42) | SMN1; SMN2FBP1PDK1HTR7DCUN1D1 | |
| SCHEMBL8032825 | 0.72 | HSP90AA1 (0.40) | NPC1RAB9ASMN1; SMN2TDP1PKM | |
| SCHEMBL8043989 | 0.71 | FBP1 (0.42) | NPC1RAB9AFBP1PDK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |