Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | MGAM | O43451 | 1/20 | 0.64 |
| ▸ | SI | P14410 | 1/20 | 0.64 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | APP | P05067 | 11/20 | 0.46 |
| ▸ | DDX3X | O00571 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10596042 | 0.86 | GAA (0.75) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL14557099 | 0.84 | KDM4E (0.43) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL8050989 | 0.79 | ALDH1A1 (0.60) | GAAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6375887 | 0.78 | GAA (1.00) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL8047389 | 0.75 | CA1 (0.49) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL9360268 | 0.75 | GAA (0.60) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL28353374 | 0.75 | ALDH1A1 (0.48) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL8044729 | 0.75 | SMN1; SMN2 (0.43) | GAAMGAMSIMGAM2MAPT | |
| SCHEMBL972899 | 0.75 | MGAM (0.60) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL13401040 | 0.74 | KDM4E (0.64) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |