SCHEMBL8050989

SCHEMBL8050989

Cc1ccc(-c2nnc(S)s2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.60
SMN1; SMN2 Q16637 2/20 0.60
LMNA P02545 1/20 0.60
RAB9A P51151 5/20 0.47
NPC1 O15118 3/20 0.47
HPGD P15428 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41
HDAC1 Q13547 2/20 0.40
ALOX15 P16050 1/20 0.40
PTGS2 P35354 1/20 0.40
HDAC2 Q92769 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40
KDM4E B2RXH2 3/20 0.40
GAA P10253 1/20 0.40
TP53 P04637 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
COMT P21964 1/20 0.39
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
ALOX5 P09917 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14557099 0.89 KDM4E (0.43) ALDH1A1SMN1; SMN2LMNARAB9ANPC1
SCHEMBL10000252 0.84 ALDH1A1 (0.72) ALDH1A1SMN1; SMN2LMNARAB9ANPC1
SCHEMBL14557095 0.80 SNCA (0.37) ALDH1A1SMN1; SMN2LMNAHPGDPTGS2
SCHEMBL972899 0.79 MGAM (0.60) ALDH1A1SMN1; SMN2LMNARAB9ANPC1
SCHEMBL8044729 0.79 SMN1; SMN2 (0.43) SMN1; SMN2RAB9ANPC1NPSR1HDAC1
SCHEMBL28353374 0.79 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2LMNARAB9ANPC1
SCHEMBL8047389 0.79 CA1 (0.49) ALDH1A1SMN1; SMN2LMNARAB9ANPC1
SCHEMBL9360268 0.79 GAA (0.60) ALDH1A1SMN1; SMN2LMNARAB9ANPC1
SCHEMBL8042941 0.79 GAA (0.64) ALDH1A1SMN1; SMN2RAB9ANPC1HPGD
SCHEMBL13401040 0.79 KDM4E (0.64) ALDH1A1SMN1; SMN2RAB9ANPC1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111116506-B Synthesis method of arylmercapto diazole derivative 浙江大学衢州研究院 2024-03-08 CN disclosed
CN-111116506-A Synthetic method of aromatic mercapto-diazole derivative 浙江大学衢州研究院 2020-05-08 CN disclosed
CN-110698422-A Synthetic method of aromatic mercapto-diazole derivative 浙江大学 2020-01-17 CN disclosed
US-7695888-B2 Photosensitive lithographic printing plate FUJIFILM CORPORATION (JP) 2010-04-13 US disclosed
US-7695888-B2 Photosensitive lithographic printing plate FUJIFILM CORPORATION (JP) 2010-04-13 US disclosed
US-20070184383-A1 Photosensitive composition, photosensitive planographic printing plate material, and recording method of planographic printing plate material KONICA MINOLTA MEDICAL & GRAPHIC, INC. 2007-08-09 US disclosed
US-20070184383-A1 Photosensitive composition, photosensitive planographic printing plate material, and recording method of planographic printing plate material KONICA MINOLTA MEDICAL & GRAPHIC, INC. 2007-08-09 US disclosed
US-6080772-A 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY SUGEN, INC. (US) 2000-06-27 US disclosed