Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050410 | 0.90 | ALDH1A1 (0.46) | PTGS2KMT2AALDH1A1RAB9AMAPT | |
| SCHEMBL8048328 | 0.88 | PKM (0.41) | PTGS2KMT2AALDH1A1RAB9AMAPT | |
| SCHEMBL8033160 | 0.88 | PKM (0.51) | PTGS2KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL8052304 | 0.88 | ALDH1A1 (0.49) | PTGS2KMT2AALDH1A1RAB9AMAPT | |
| SCHEMBL8032424 | 0.87 | PKM (0.45) | PTGS2KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL8035046 | 0.86 | PTGS2 (0.53) | PTGS2KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL8045105 | 0.86 | ALDH1A1 (0.40) | PTGS2KMT2AALDH1A1RAB9AMAPT | |
| SCHEMBL8043014 | 0.86 | RECQL (0.49) | PTGS2KMT2AALDH1A1RAB9AMAPT | |
| SCHEMBL8042108 | 0.84 | PDK1 (0.50) | KMT2AALDH1A1RAB9AMAPTHPGD | |
| SCHEMBL8042805 | 0.83 | ALDH1A1 (0.48) | KMT2AALDH1A1RAB9AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |