Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 6/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045340 | 0.81 | KDM4E (0.63) | KDM4ENPC1RAB9AHDAC6CYP3A4 | |
| SCHEMBL8041924 | 0.81 | TSHR (0.66) | KDM4ECYP3A4TSHRMEN1KMT2A | |
| SCHEMBL8044774 | 0.80 | KDM4E (0.43) | KDM4ENPC1RAB9ATSHRL3MBTL1 | |
| SCHEMBL8045928 | 0.80 | TSHR (0.52) | KDM4ENPC1RAB9ATSHRL3MBTL1 | |
| SCHEMBL8048062 | 0.80 | KDM4E (0.58) | KDM4ENPC1RAB9AHDAC6CYP3A4 | |
| SCHEMBL8042512 | 0.79 | RAB9A (0.50) | KDM4ENPC1RAB9ATSHRL3MBTL1 | |
| SCHEMBL6247006 | 0.78 | KDM4E (1.00) | KDM4ENPC1RAB9AHDAC6CYP3A4 | |
| SCHEMBL8043084 | 0.78 | FBP1 (0.42) | KDM4ENPC1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL8051905 | 0.78 | TSHR (0.54) | KDM4ECYP3A4TSHRMEN1KMT2A | |
| SCHEMBL8043021 | 0.78 | TSHR (0.51) | KDM4ECYP3A4TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |