Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048106 | 0.84 | KDM4E (0.56) | KDM4ENPC1RAB9AHDAC6CYP3A4 | |
| SCHEMBL8036965 | 0.82 | TSHR (0.67) | KDM4ECYP3A4TSHRSMN1; SMN2MEN1 | |
| SCHEMBL8043181 | 0.81 | KDM4E (0.63) | KDM4ENPC1RAB9AHDAC6CYP3A4 | |
| SCHEMBL8033238 | 0.81 | RAB9A (0.52) | KDM4ENPC1RAB9ACYP3A4TSHR | |
| SCHEMBL8048096 | 0.81 | MAPT (0.55) | KDM4ENPC1RAB9AHDAC6CYP3A4 | |
| SCHEMBL8043590 | 0.80 | KDM4E (0.53) | KDM4ENPC1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL8033896 | 0.80 | NPC1 (0.54) | KDM4ENPC1RAB9AHDAC6CYP3A4 | |
| SCHEMBL8048230 | 0.80 | KDM4E (0.43) | KDM4ENPC1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL8044988 | 0.80 | KDM4E (0.58) | KDM4ENPC1RAB9AHDAC6CYP3A4 | |
| SCHEMBL8044388 | 0.79 | TSHR (0.53) | KDM4ECYP3A4TSHRSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |