Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADH1B | P00325 | 1/20 | 0.41 |
| ▸ | ADH1C | P00326 | 1/20 | 0.41 |
| ▸ | ADH1A | P07327 | 1/20 | 0.41 |
| ▸ | ADH4 | P08319 | 1/20 | 0.41 |
| ▸ | ADH7 | P40394 | 1/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15806858 | 0.83 | EPHX1 (0.46) | CXCR4HSD11B1EPHX1EPHX2SMN1; SMN2 | |
| SCHEMBL7738185 | 0.81 | HSD11B1 (0.47) | HSD11B1EPHX1EPHX2ACHESMN1; SMN2 | |
| SCHEMBL8047471 | 0.79 | NCF1 (0.46) | CXCR4EPHX1ADH1BADH1CADH1A | |
| SCHEMBL8030921 | 0.78 | CXCR4 (0.48) | CXCR4EPHX1ACHEADH1BADH1C | |
| SCHEMBL711161 | 0.78 | HSD11B1 (0.36) | CXCR4HSD11B1EPHX1ACHEADH1B | |
| SCHEMBL1678544 | 0.78 | ADH1B (0.59) | CXCR4EPHX1ADH1BADH1CADH1A | |
| SCHEMBL1679033 | 0.78 | ADH1B (0.59) | CXCR4EPHX1ADH1BADH1CADH1A | |
| SCHEMBL1679102 | 0.78 | ADH1B (0.59) | CXCR4EPHX1ADH1BADH1CADH1A | |
| SCHEMBL12605183 | 0.77 | L3MBTL1 (0.47) | CXCR4EPHX1EPHX2SMN1; SMN2GNAI3 | |
| SCHEMBL23560045 | 0.76 | EPHX1 (0.41) | HSD11B1EPHX1EPHX2SMN1; SMN2GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |