Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050870 | 0.77 | MGAM (0.47) | TSHRSNCAKMT2ALMNAMAPT | |
| Bromophene SCHEMBL29429127 | 0.71 | GABRA1 (1.00) | GABRA1GABRB1GABRA2GABRB2CYP3A4 | |
| Bromophene SCHEMBL31323101 | 0.71 | GABRA1 (1.00) | GABRA1GABRB1GABRA2GABRB2CYP3A4 | |
| Bromophene SCHEMBL2783711 | 0.71 | GABRA1 (1.00) | GABRA1GABRB1GABRA2GABRB2CYP3A4 | |
| SCHEMBL8043597 | 0.70 | MGAM (0.40) | GABRA1GABRA2GABRB2MAPTMGAM | |
| SCHEMBL12666319 | 0.67 | GABRA1 (0.57) | GABRA1GABRB1GABRA2GABRB2CYP3A4 | |
| SCHEMBL30471834 | 0.66 | RAB9A (0.60) | GABRA1GABRB1GABRA2GABRB2TDP1 | |
| SCHEMBL7197008 | 0.66 | RAB9A (0.60) | GABRA1GABRB1GABRA2GABRB2TDP1 | |
| SCHEMBL18224 | 0.63 | CYP3A4 (1.00) | GABRA1GABRB1GABRA2GABRB2CYP3A4 | |
| SCHEMBL8047389 | 0.63 | CA1 (0.49) | SNCALMNAMGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |