Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | SI | P14410 | 3/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HPN | P05981 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048082 | 0.83 | ALDH1A1 (0.47) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL8050870 | 0.80 | MGAM (0.47) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL970693 | 0.75 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDHSD17B10GUSB | |
| SCHEMBL29678599 | 0.72 | ALDH1A1 (0.65) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL8045944 | 0.72 | ALDH1A1 (0.65) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL8047389 | 0.71 | CA1 (0.49) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL15876599 | 0.70 | MGAM (0.49) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL8042809 | 0.70 | ALDH1A1 (0.64) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL8043262 | 0.70 | GABRA1 (0.52) | MGAMGAASIMGAM2HPGD | |
| SCHEMBL8045495 | 0.69 | HDAC1 (0.46) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |