Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | LOX | P28300 | 1/20 | 0.34 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2686249 | 0.79 | KDM4E (0.60) | CYP19A1KDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL8042809 | 0.75 | ALDH1A1 (0.64) | KDM4EALDH1A1MAPTL3MBTL1SNCA | |
| SCHEMBL8042130 | 0.74 | HSD17B1 (0.46) | IDO1KDM4EALDH1A1HSD17B1NOTUM | |
| SCHEMBL8042639 | 0.74 | PIK3CD (0.43) | KDM4EALDH1A1MAPTL3MBTL1MGAM | |
| SCHEMBL969939 | 0.74 | KDM4E (0.59) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL14557099 | 0.72 | KDM4E (0.43) | KDM4EALDH1A1MAPTL3MBTL1SNCA | |
| SCHEMBL14557095 | 0.72 | SNCA (0.37) | KDM4EALDH1A1MAPTL3MBTL1SNCA | |
| SCHEMBL8042087 | 0.72 | PIM1 (0.47) | KDM4EALDH1A1MAPTL3MBTL1SNCA | |
| SCHEMBL4027001 | 0.72 | IDO1 (0.55) | CYP19A1IDO1ADORA2AADORA1CCNC | |
| SCHEMBL972899 | 0.72 | MGAM (0.60) | ADORA2AADORA1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |