Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | MGAM | O43451 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | SI | P14410 | 4/20 | 0.56 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.49 |
| ▸ | QPCT | Q16769 | 1/20 | 0.48 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043402 | 0.79 | CYP19A1 (0.41) | KDM4EALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL10284642 | 0.79 | ALDH1A1 (0.58) | KDM4EALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL2685703 | 0.76 | KDM4E (0.53) | KDM4EALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL603197 | 0.74 | KDM4E (0.65) | KDM4EALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL369633 | 0.74 | KDM4E (1.00) | KDM4EALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL4027001 | 0.72 | IDO1 (0.55) | CYP19A1 | |
| SCHEMBL1143676 | 0.72 | KDM4E (1.00) | KDM4EALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL11331186 | 0.72 | KDM4E (0.66) | KDM4EALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL11341897 | 0.71 | KDM4E (0.67) | KDM4EALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL21408723 | 0.71 | KDM4E (0.66) | KDM4EALDH1A1MAPTL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2804610-B1 | ORGANIC COMPOUNDS | UNIV ROCKEFELLER (US) | 2018-10-31 | — | — | EP | disclosed |
| US-9303044-B2 | 7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-A]pyrimidin-5-ones for the treatment of thrombotic disorders | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-04-05 | — | — | US | disclosed |
| US-9303044-B2 | 7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-A]pyrimidin-5-ones for the treatment of thrombotic disorders | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-04-05 | — | — | US | disclosed |
| US-9303044-B2 | 7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-A]pyrimidin-5-ones for the treatment of thrombotic disorders | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-04-05 | — | — | US | disclosed |
| EP-2121687-B1 | TRICYCLIC AMINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2015-10-14 | — | — | EP | disclosed |
| US-20150050325-A1 | ORGANIC COMPOUNDS | THE ROCKEFELLER UNIVERSITY (US) | 2015-02-19 | — | — | US | disclosed |
| US-20150050325-A1 | ORGANIC COMPOUNDS | THE ROCKEFELLER UNIVERSITY (US) | 2015-02-19 | — | — | US | disclosed |
| US-20150050325-A1 | ORGANIC COMPOUNDS | THE ROCKEFELLER UNIVERSITY (US) | 2015-02-19 | — | — | US | disclosed |
| EP-2804610-A2 | ORGANIC COMPOUNDS | The Rockefeller University (US) | 2014-11-26 | — | — | EP | disclosed |
| US-8785468-B2 | Phenylalanine amide derivatives useful for treating insulin-related diseases and conditions | AMGEN INC. (US) | 2014-07-22 | — | — | US | disclosed |
| WO-2013109632-A2 | ORGANIC COMPOUNDS | THE ROCKEFELLER UNIVERSITY (US) | 2013-07-25 | — | — | WO | disclosed |
| WO-2013109632-A2 | ORGANIC COMPOUNDS | THE ROCKEFELLER UNIVERSITY (US) | 2013-07-25 | — | — | WO | disclosed |
| US-20120115811-A1 | PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | AMGEN INC. (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120115811-A1 | PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | AMGEN INC. (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120115811-A1 | PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | AMGEN INC. (US) | 2012-05-10 | — | — | US | disclosed |
| WO-2010093849-A2 | PHENYLALANINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | AMGEN INC. (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010093849-A2 | PHENYLALANINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | AMGEN INC. (US) | 2010-08-19 | — | — | WO | disclosed |
| US-20100093718-A1 | Compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | US | disclosed |
| EP-2121687-A2 | TRICYCLIC AMINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS | Astex Therapeutics Limited (GB) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008078100-A2 | TRICYCLIC AMINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115811-A1 | PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | IAPP, INSR, AMY2A | KDM4E 3283/4885ALDH1A1 2340/4885MAPT 4112/4885 |
| US-20150050325-A1 | ORGANIC COMPOUNDS | VCAM1, ICAM1, PLAT | KDM4E 3409/4885ALDH1A1 426/4885MAPT 1501/4885 |
| US-20100093718-A1 | Compounds | FGFR1, FGFR2, PDGFRB | KDM4E 1582/4885ALDH1A1 379/4885MAPT 3238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.