Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15237377 | 0.91 | TSHR (0.47) | TSHRCA1CA2L3MBTL1LMNA | |
| SCHEMBL11615218 | 0.89 | TSHR (0.56) | TSHRCA1CA2L3MBTL1LMNA | |
| SCHEMBL28042796 | 0.86 | CA1 (0.55) | TSHRCA1CA2L3MBTL1LMNA | |
| SCHEMBL27966661 | 0.86 | CA2 (0.65) | TSHRCA1CA2L3MBTL1LMNA | |
| SCHEMBL11149235 | 0.85 | TSHR (0.52) | TSHRCA1CA2L3MBTL1LMNA | |
| SCHEMBL15237376 | 0.84 | L3MBTL1 (0.49) | TSHRCA1CA2L3MBTL1LMNA | |
| SCHEMBL5978900 | 0.84 | CA2 (0.62) | TSHRCA1CA2L3MBTL1LMNA | |
| SCHEMBL6895660 | 0.84 | CA1 (0.58) | TSHRCA1CA2L3MBTL1LMNA | |
| SCHEMBL8107918 | 0.83 | TSHR (0.54) | TSHRCA1CA2L3MBTL1LMNA | |
| SCHEMBL495444 | 0.82 | CA1 (0.65) | TSHRCA1CA2L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170015704-A1 | AMINOTHIAZOLES AND THEIR USES | NOVARTIS AG (CH) | 2017-01-19 | — | — | US | disclosed |
| US-9492496-B2 | Aminothiazoles and their uses | NOVARTIS AG (CH) | 2016-11-15 | — | — | US | disclosed |
| US-20140274878-A1 | AMINOTHIAZOLES AND THEIR USES | NOVARTIS AG (CH) | 2014-09-18 | — | — | US | disclosed |
| US-20130231275-A1 | AMINIOTHIAZOLES AND THEIR USES | NOVARTIS AG (CH) | 2013-09-05 | — | — | US | disclosed |
| WO-2009074605-A1 | AMINOTHIAZOLES AND THEIR USES | NOVARTIS AG (CH) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231275-A1 | AMINIOTHIAZOLES AND THEIR USES | ABAT, AADAT, AADAC | TSHR 3356/4885CA1 4731/4885CA2 3902/4885 |
| US-20170015704-A1 | AMINOTHIAZOLES AND THEIR USES | ABAT, AADAT, BCAT2 | TSHR 3438/4885CA1 4486/4885CA2 2495/4885 |
| US-20140274878-A1 | AMINOTHIAZOLES AND THEIR USES | ABAT, AADAT, BCAT2 | TSHR 3438/4885CA1 4486/4885CA2 2495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.