Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 2/20 | 0.37 |
| ▸ | SELE | P16581 | 2/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051724 | 0.83 | MAPK8 (0.54) | ICAM1SELEVCAM1GAAMAPK8 | |
| SCHEMBL8050241 | 0.81 | CA1 (0.35) | MAPK8MAPK9MAPK10MAPTMEN1 | |
| SCHEMBL8043817 | 0.81 | MAPK8 (0.37) | MAPK8MAPK9MAPK10MAPTMEN1 | |
| SCHEMBL8043833 | 0.81 | MAPK8 (0.34) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL8042354 | 0.80 | MAPK8 (0.34) | MAPK8MAPK9MAPK10 | |
| SCHEMBL8048119 | 0.79 | MAPK8 (0.38) | GAAMAPK8MAPK9MAPK10KMT2A | |
| SCHEMBL8044039 | 0.77 | ALDH1A1 (0.37) | GAAMAPK8MAPK9MAPK10MEN1 | |
| SCHEMBL8044752 | 0.77 | MAPK8 (0.33) | MAPK8MAPK9MAPK10 | |
| SCHEMBL8041884 | 0.77 | MAPK8 (0.36) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL8043583 | 0.76 | AKT1 (0.33) | GAAMAPK8MAPK9MAPK10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |