Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043593 | 0.81 | ICAM1 (0.37) | MAPK8MAPK9ALDH1A1MAPK10NPC1 | |
| SCHEMBL8051724 | 0.79 | MAPK8 (0.54) | MAPK8MAPK9ALDH1A1SMN1; SMN2MAPK10 | |
| SCHEMBL8043817 | 0.77 | MAPK8 (0.37) | MAPK8MAPK9ALDH1A1MAPK10NPC1 | |
| SCHEMBL8042354 | 0.76 | MAPK8 (0.34) | MAPK8MAPK9MAPK10 | |
| SCHEMBL8034033 | 0.76 | ALDH1A1 (0.36) | MAPK8MAPK9ALDH1A1SMN1; SMN2MAPK10 | |
| SCHEMBL8048119 | 0.75 | MAPK8 (0.38) | MAPK8MAPK9ALDH1A1MAPK10 | |
| SCHEMBL21899248 | 0.74 | FFAR2 (0.38) | — | |
| SCHEMBL8047234 | 0.74 | RXRA (0.43) | MAPK8MAPK9ALDH1A1SMN1; SMN2MAPK10 | |
| SCHEMBL8044752 | 0.74 | MAPK8 (0.33) | MAPK8MAPK9MAPK10 | |
| SCHEMBL8041884 | 0.74 | MAPK8 (0.36) | MAPK8MAPK9ALDH1A1MAPK10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |