Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042681 | 0.81 | PDK1 (0.62) | ILKSMN1; SMN2KMT2ALMNAHTT | |
| SCHEMBL8032835 | 0.81 | PKM (0.47) | ILKSMN1; SMN2KMT2ALMNATP53 | |
| SCHEMBL8051673 | 0.81 | SCD (0.46) | ILKSMN1; SMN2KMT2ALMNATP53 | |
| SCHEMBL8044884 | 0.79 | PKM (0.50) | ILKSMN1; SMN2KMT2ALMNATP53 | |
| SCHEMBL8050079 | 0.79 | ILK (0.51) | ILKSMN1; SMN2KMT2ALMNATP53 | |
| SCHEMBL8044071 | 0.77 | ALDH1A1 (0.51) | KMT2ATP53MAPTALDH1A1HPGD | |
| SCHEMBL8043189 | 0.76 | PKM (0.47) | ILKSMN1; SMN2KMT2ALMNATP53 | |
| SCHEMBL8044433 | 0.75 | KMT2A (0.47) | ILKSMN1; SMN2KMT2ALMNATP53 | |
| SCHEMBL11605260 | 0.75 | KMT2A (0.58) | ILKSMN1; SMN2KMT2ALMNATP53 | |
| SCHEMBL12799099 | 0.74 | ALDH1A1 (0.59) | ILKSMN1; SMN2KMT2ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |