Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044462 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8047063 | 0.80 | TSHR (0.51) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8042116 | 0.80 | SMN1; SMN2 (0.41) | ALDH1A1KDM4ESMN1; SMN2MAPTRAB9A | |
| SCHEMBL8043752 | 0.80 | KDM4E (0.48) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8048173 | 0.79 | MAPT (0.36) | ALDH1A1HPGDCYP2C9SMN1; SMN2MAPT | |
| SCHEMBL8044772 | 0.79 | MAPT (0.38) | ALDH1A1CYP2C9SMN1; SMN2MAPTCYP2C19 | |
| SCHEMBL8048718 | 0.78 | RPA1 (0.50) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8042974 | 0.78 | KDM4E (0.52) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8044342 | 0.77 | ALPG (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL8050065 | 0.77 | KDM4E (0.52) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |