Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743263 | 0.83 | SMN1; SMN2 (0.46) | MAPTALDH1A1CYP1A2POLB | |
| SCHEMBL28185162 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAACA12CA1 | |
| SCHEMBL8043762 | 0.77 | MTNR1B (0.52) | LMNAMAPTALDH1A1PTPRCMEN1 | |
| SCHEMBL10344871 | 0.77 | L3MBTL1 (0.55) | L3MBTL1NPSR1LMNAMAPTALDH1A1 | |
| SCHEMBL1743175 | 0.75 | PLAU (0.33) | MAPTALDH1A1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5255920 | 0.74 | — | — | |
| SCHEMBL8102792 | 0.73 | CYP1A2 (0.73) | L3MBTL1LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL4837973 | 0.73 | SNCA (0.33) | — | |
| SCHEMBL306383 | 0.72 | PDK1 (0.71) | NPSR1LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL1977535 | 0.71 | ALDH1A1 (0.36) | NPSR1LMNAMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000045-A1 | 1,4-DISUBSTITUTED PIPERAZINES | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 2000-05-17 | — | — | EP | claimed |
| WO-1999006382-A1 | 1,4-DISUBSTITUTED PIPERAZINES | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-02-11 | — | — | WO | claimed |
| EP-1000045-A1 | 1,4-DISUBSTITUTED PIPERAZINES | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999006382-A1 | 1,4-DISUBSTITUTED PIPERAZINES | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-02-11 | — | — | WO | disclosed |