Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL968101 | 0.79 | KDM4E (0.61) | KDM4EALDH1A1PIM1PIM3PIM2 | |
| SCHEMBL30494574 | 0.79 | ALDH1A1 (0.66) | KDM4EALDH1A1PIM1PIM3PIM2 | |
| SCHEMBL2359695 | 0.79 | ALDH1A1 (0.66) | KDM4EALDH1A1PIM1PIM3PIM2 | |
| SCHEMBL20928910 | 0.78 | KEAP1 (0.46) | KDM4EALDH1A1KMO | |
| SCHEMBL968154 | 0.77 | MGAM (0.43) | ALDH1A1GUSB | |
| SCHEMBL20928989 | 0.74 | KEAP1 (0.42) | KDM4EALDH1A1MAPK14NPC1RAB9A | |
| SCHEMBL8840148 | 0.73 | TTR (0.47) | KDM4EALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL971661 | 0.73 | TDP1 (0.46) | ALDH1A1 | |
| SCHEMBL19814620 | 0.72 | TTR (0.46) | KDM4EALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL30824456 | 0.72 | ROCK2 (0.47) | KDM4EALDH1A1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |