Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.42 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042995 | 0.81 | KDM4E (0.49) | GRK6HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8051673 | 0.81 | SCD (0.46) | GRK6HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8048199 | 0.81 | PDK1 (0.53) | GRK6HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8050079 | 0.79 | ILK (0.51) | HPGDKDM4ESMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL8034043 | 0.78 | KDM4E (0.48) | HPGDCYP1A2KDM4ESMN1; SMN2NFKB1 | |
| SCHEMBL8045981 | 0.75 | GRK6 (0.56) | GRK6HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8047025 | 0.74 | GRK6 (0.52) | GRK6HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8042533 | 0.74 | HDAC6 (0.53) | CYP3A4KDM4ESMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL8047977 | 0.74 | KDM4E (0.47) | HPGDKDM4ESMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL8050857 | 0.73 | HSD17B10 (0.48) | HPGDCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |