Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044315 | 0.85 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8046377 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8042913 | 0.84 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8032431 | 0.83 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8042813 | 0.80 | KDM4E (0.52) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8047964 | 0.80 | KDM4E (0.54) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8044969 | 0.80 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8046541 | 0.79 | KDM4E (0.47) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8042974 | 0.79 | KDM4E (0.52) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 | |
| SCHEMBL8034048 | 0.79 | KDM4E (0.53) | ALDH1A1KDM4EHPGDCYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |