SCHEMBL8042913

SCHEMBL8042913

Cc1nc(-c2ccccc2)sc1-c1nnc(Sc2ncc(NC(=O)c3ccccc3)s2)n1-c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
HPGD P15428 4/20 0.44
KDM4E B2RXH2 3/20 0.44
CYP1A2 P05177 2/20 0.44
CYP2C9 P11712 2/20 0.44
HDAC6 Q9UBN7 4/20 0.43
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C19 P33261 1/20 0.42
MAPT P10636 4/20 0.40
RAB9A P51151 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
TSHR P16473 1/20 0.38
ADORA3 P0DMS8 2/20 0.38
ADORA2A P29274 1/20 0.38
ADORA1 P30542 1/20 0.38
PTK2 Q05397 2/20 0.38
HDAC1 Q13547 2/20 0.38
HDAC2 Q92769 2/20 0.38
HDAC8 Q9BY41 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8044462 0.84 ALDH1A1 (0.48) ALDH1A1HPGDKDM4ECYP1A2CYP2C9
SCHEMBL8042860 0.81 HDAC6 (0.44) HDAC6RAB9ASMN1; SMN2ADORA3PTK2
SCHEMBL8044315 0.81 ALDH1A1 (0.51) ALDH1A1HPGDKDM4ECYP1A2CYP2C9
SCHEMBL8043803 0.80 HDAC6 (0.41) HDAC6MAPTRAB9ASMN1; SMN2TSHR
SCHEMBL8046377 0.79 ALDH1A1 (0.47) ALDH1A1HPGDKDM4ECYP1A2CYP2C9
SCHEMBL8043654 0.79 TSHR (0.52) ALDH1A1HPGDKDM4ECYP1A2CYP2C9
SCHEMBL8042586 0.79 RPA1 (0.47) KDM4EHDAC6MAPTRAB9ASMN1; SMN2
SCHEMBL8032431 0.79 ALDH1A1 (0.47) ALDH1A1HPGDKDM4ECYP1A2CYP2C9
SCHEMBL8045350 0.78 SMN1; SMN2 (0.39) ALDH1A1HDAC6MAPTRAB9ASMN1; SMN2
SCHEMBL8049866 0.76 PKM (0.45) ALDH1A1HPGDKDM4EHDAC6CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080772-A 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY SUGEN, INC. (US) 2000-06-27 US disclosed
WO-1998027092-A1 THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION SUGEN, INC. (US) 1998-06-25 WO disclosed