Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GGT1 | P19440 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043963 | 0.89 | ATM (0.42) | LMNAHSD17B10ALDH1A1KMT2APOLB | |
| SCHEMBL8043817 | 0.82 | MAPK8 (0.37) | ALDH1A1KMT2AMEN1NPC1NPSR1 | |
| SCHEMBL8042976 | 0.81 | HDAC6 (0.43) | LMNAALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL8042354 | 0.81 | MAPK8 (0.34) | LOXL2 | |
| SCHEMBL8043583 | 0.80 | AKT1 (0.33) | LOXL2 | |
| SCHEMBL8048119 | 0.80 | MAPK8 (0.38) | ALDH1A1KMT2APOLBLOXL2 | |
| SCHEMBL8044752 | 0.79 | MAPK8 (0.33) | LOXL2 | |
| SCHEMBL8041884 | 0.79 | MAPK8 (0.36) | ALDH1A1TSHRNPC1RAB9ALOXL2 | |
| SCHEMBL8044039 | 0.79 | ALDH1A1 (0.37) | HSD17B10ALDH1A1TSHRKMT2APOLB | |
| SCHEMBL8034366 | 0.78 | ALDH1A1 (0.45) | LMNAHSD17B10ALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |