Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043927 | 0.88 | ATM (0.47) | ALDH1A1LMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL8052110 | 0.80 | ALDH1A1 (0.45) | ALDH1A1LMNAHSD17B10TSHRKMT2A | |
| SCHEMBL8050254 | 0.78 | HDAC6 (0.45) | ALDH1A1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL8032483 | 0.78 | MAPK8 (0.57) | ALDH1A1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL8044491 | 0.78 | LMNA (0.48) | ALDH1A1LMNAHSD17B10TSHRKMT2A | |
| SCHEMBL8043915 | 0.78 | MAPK8 (0.37) | ALDH1A1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL8043957 | 0.78 | MAPK8 (0.33) | — | |
| SCHEMBL8048610 | 0.76 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10TSHRKMT2A | |
| SCHEMBL8044476 | 0.76 | MAPK8 (0.33) | RAB9AMAPT | |
| SCHEMBL8044265 | 0.75 | MAPK8 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |