Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 4/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.36 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | SAT1 | P21673 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033603 | 0.98 | SIGMAR1 (0.43) | SIGMAR1GNAI3GNAO1GNAI1HDAC8 | |
| SCHEMBL8031282 | 0.88 | GNAI3 (0.46) | SIGMAR1GNAI3GNAO1GNAI1HDAC8 | |
| SCHEMBL8044995 | 0.85 | CHRM5 (0.48) | SIGMAR1GNAI3GNAO1GNAI1HRH3 | |
| SCHEMBL8047476 | 0.85 | CHRM5 (0.48) | SIGMAR1GNAI3GNAO1GNAI1HRH3 | |
| SCHEMBL9911454 | 0.80 | CARM1 (0.46) | SIGMAR1GNAI3GNAO1GNAI1ACE2 | |
| SCHEMBL8046130 | 0.79 | ALDH1A1 (0.50) | ALDH1A1 | |
| SCHEMBL25666721 | 0.79 | PRMT6 (0.55) | SIGMAR1GNAI3GNAO1GNAI1HRH3 | |
| SCHEMBL13661593 | 0.79 | CARM1 (0.45) | SIGMAR1GNAI3GNAO1GNAI1ACE2 | |
| SCHEMBL4395015 | 0.77 | ACE2 (0.61) | SIGMAR1HDAC8ACE2KDM1APRMT6 | |
| SCHEMBL23423425 | 0.76 | ALDH1A1 (0.48) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |