Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043237 | 0.85 | TSHR (0.39) | HDAC6TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL8044387 | 0.84 | TSHR (0.37) | HDAC6TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL8043803 | 0.84 | HDAC6 (0.41) | HDAC6TSHRPOLBHTTSMN1; SMN2 | |
| SCHEMBL8047165 | 0.82 | NPC1 (0.44) | TSHRMEN1KMT2AALDH1A1HTT | |
| SCHEMBL8052238 | 0.79 | POLB (0.45) | HDAC6TSHRMEN1KMT2APOLB | |
| SCHEMBL8712945 | 0.79 | TP53 (0.51) | TSHRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL8034049 | 0.78 | TSHR (0.58) | TSHRMEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL8048173 | 0.78 | MAPT (0.36) | HDAC6TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL8042081 | 0.78 | TSHR (0.44) | TSHRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL8044735 | 0.78 | SMN1; SMN2 (0.40) | HDAC6HTTSMN1; SMN2NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |