Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 7/20 | 0.39 |
| ▸ | CA2 | P00918 | 7/20 | 0.39 |
| ▸ | CA9 | Q16790 | 7/20 | 0.39 |
| ▸ | CA4 | P22748 | 5/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034578 | 0.82 | EP300 (0.46) | PTGS2HSD17B10TP53CA1CA2 | |
| SCHEMBL8032781 | 0.81 | TP53 (0.46) | HSD17B10JAK2TP53TLR9ALDH1A1 | |
| SCHEMBL8032540 | 0.81 | ALDH1A1 (0.53) | HSD17B10TP53ALDH1A1PKMHPGD | |
| SCHEMBL8032472 | 0.80 | PTGS2 (0.48) | PTGS2CA1CA2CA9CA4 | |
| SCHEMBL8048040 | 0.80 | HPGD (0.52) | HSD17B10JAK2TP53TLR9ALDH1A1 | |
| SCHEMBL8032741 | 0.79 | PTGS2 (0.48) | PTGS2HSD17B10JAK2TP53TLR9 | |
| SCHEMBL8042445 | 0.79 | HSD17B10 (0.44) | HSD17B10JAK2TP53TLR9ALDH1A1 | |
| SCHEMBL8051272 | 0.78 | SMN1; SMN2 (0.49) | HSD17B10JAK2TP53TLR9ALDH1A1 | |
| SCHEMBL8044697 | 0.78 | HSD17B10 (0.43) | HSD17B10JAK2TP53TLR9ALDH1A1 | |
| SCHEMBL8047806 | 0.78 | MAPT (0.43) | PTGS2HSD17B10JAK2TP53TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |