Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043233 | 0.82 | PTGS2 (0.56) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8032354 | 0.82 | ALDH1A1 (0.46) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8044963 | 0.82 | ALDH1A1 (0.42) | KMT2A | |
| SCHEMBL8043945 | 0.81 | ALDH1A1 (0.57) | KMT2A | |
| SCHEMBL8050817 | 0.81 | PTGS2 (0.57) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8050034 | 0.81 | PTGS2 (0.43) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8042731 | 0.81 | ALDH1A1 (0.41) | KMT2A | |
| SCHEMBL8044845 | 0.80 | PTGS2 (0.46) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8032329 | 0.80 | RECQL (0.53) | PTGS2KMT2A | |
| SCHEMBL8046282 | 0.80 | SMN1; SMN2 (0.49) | PTGS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |