Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.41 |
| ▸ | HTT | P42858 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051721 | 0.85 | ALDH1A1 (0.47) | ALDH1A1HTTLMNAMAPK1TP53 | |
| SCHEMBL8048309 | 0.84 | ALDH1A1 (0.52) | ALDH1A1HTTLMNAMAPK1TP53 | |
| SCHEMBL8033678 | 0.83 | ALDH1A1 (0.43) | ALDH1A1HTTLMNAMAPK1TP53 | |
| SCHEMBL8052176 | 0.80 | MAPK1 (0.44) | ALDH1A1HTTLMNAMAPK1TP53 | |
| SCHEMBL8050069 | 0.80 | ALDH1A1 (0.45) | ALDH1A1HTTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8051093 | 0.80 | MAPK8 (0.46) | ALDH1A1HTTLMNAMAPK1TP53 | |
| SCHEMBL8042545 | 0.79 | ALDH1A1 (0.36) | ALDH1A1HTTLMNAMAPK1TP53 | |
| SCHEMBL8041836 | 0.79 | ALDH1A1 (0.42) | ALDH1A1HTTLMNAMAPK1TP53 | |
| SCHEMBL8032525 | 0.78 | POLB (0.42) | ALDH1A1HTTLMNAMAPK1TP53 | |
| SCHEMBL8033933 | 0.78 | MITF (0.39) | ALDH1A1HTTLMNAMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |