Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 7/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042845 | 0.85 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2TSHRHSD17B10TP53 | |
| SCHEMBL8043646 | 0.85 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2TSHRHSD17B10TP53 | |
| SCHEMBL8042672 | 0.84 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2TSHRHSD17B10TP53 | |
| SCHEMBL8044841 | 0.84 | KDM4E (0.49) | ALDH1A1SMN1; SMN2TSHRHSD17B10TP53 | |
| SCHEMBL8033930 | 0.81 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2TSHRHSD17B10TP53 | |
| SCHEMBL8046081 | 0.81 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2TSHRHSD17B10TP53 | |
| SCHEMBL8046903 | 0.81 | HPGD (0.50) | ALDH1A1SMN1; SMN2TSHRHSD17B10TP53 | |
| SCHEMBL8048168 | 0.81 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HSD17B10TP53MAPT | |
| SCHEMBL8032741 | 0.80 | PTGS2 (0.48) | ALDH1A1SMN1; SMN2TSHRHSD17B10TP53 | |
| SCHEMBL8044847 | 0.80 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2TSHRHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |