Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045286 | 0.90 | KMT2A (0.46) | ALDH1A1KMT2AMEN1SMN1; SMN2TP53 | |
| SCHEMBL8047172 | 0.87 | SMN1; SMN2 (0.44) | ALDH1A1KMT2AMEN1SMN1; SMN2TP53 | |
| SCHEMBL8043141 | 0.85 | SMN1; SMN2 (0.42) | ALDH1A1KMT2AMEN1SMN1; SMN2TP53 | |
| SCHEMBL8041873 | 0.85 | SMN1; SMN2 (0.45) | ALDH1A1KMT2AMEN1SMN1; SMN2TP53 | |
| SCHEMBL8048727 | 0.84 | CYP1A2 (0.43) | ALDH1A1SMN1; SMN2TP53HSD17B10LMNA | |
| SCHEMBL8042780 | 0.83 | KDM4E (0.43) | ALDH1A1KMT2AMEN1SMN1; SMN2TP53 | |
| SCHEMBL8043965 | 0.83 | PDK1 (0.50) | ALDH1A1KMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL8046507 | 0.83 | KDM4E (0.49) | ALDH1A1KMT2AMEN1SMN1; SMN2TP53 | |
| SCHEMBL8044433 | 0.82 | KMT2A (0.47) | ALDH1A1KMT2AMEN1SMN1; SMN2TP53 | |
| SCHEMBL8033934 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |