SCHEMBL8048727

SCHEMBL8048727

c1ccc(CCn2nnc(Sc3nc4ccccc4s3)n2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.43
MAPK1 P28482 4/20 0.43
CYP2D6 P10635 3/20 0.43
CYP2C19 P33261 3/20 0.43
L3MBTL1 Q9Y468 3/20 0.43
CYP3A4 P08684 2/20 0.43
HIF1A Q16665 1/20 0.43
ALDH1A1 P00352 6/20 0.43
HPGD P15428 6/20 0.43
HSD17B10 Q99714 3/20 0.43
FBP1 P09467 2/20 0.43
ADRA2A P08913 1/20 0.43
ADORA3 P0DMS8 1/20 0.43
DRD2 P14416 1/20 0.43
ALOX15 P16050 1/20 0.43
ADRA2B P18089 1/20 0.43
ADRA2C P18825 1/20 0.43
DRD1 P21728 1/20 0.43
MC5R P33032 1/20 0.43
OPRM1 P35372 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8711423 0.90 GAA (0.37) CYP1A2MAPK1CYP2D6CYP2C19L3MBTL1
SCHEMBL8052354 0.88 L3MBTL1 (0.46) CYP1A2MAPK1CYP2D6CYP2C19L3MBTL1
SCHEMBL8046507 0.85 KDM4E (0.49) CYP2D6L3MBTL1ALDH1A1HPGDTDP1
SCHEMBL8045191 0.85 FBP1 (0.48) CYP1A2MAPK1CYP2D6CYP2C19L3MBTL1
SCHEMBL8032818 0.84 HSP90AA1 (0.39) MAPK1L3MBTL1ALDH1A1HPGDHSD17B10
SCHEMBL8045221 0.84 ALDH1A1 (0.45) CYP2D6ALDH1A1HPGDHSD17B10NPC1
SCHEMBL8043965 0.84 PDK1 (0.50) CYP1A2MAPK1L3MBTL1CYP3A4ALDH1A1
SCHEMBL8046519 0.83 HSP90AA1 (0.49) CYP1A2MAPK1CYP2D6CYP2C19L3MBTL1
SCHEMBL8041981 0.82 FBP1 (0.50) CYP1A2MAPK1CYP2D6CYP2C19L3MBTL1
SCHEMBL8043551 0.81 SMN1; SMN2 (0.51) CYP1A2MAPK1CYP2D6CYP2C19L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080772-A 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY SUGEN, INC. (US) 2000-06-27 US disclosed