Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045221 | 0.90 | ALDH1A1 (0.45) | KMT2AALDH1A1MEN1TP53SMN1; SMN2 | |
| SCHEMBL8041873 | 0.87 | SMN1; SMN2 (0.45) | KMT2AALDH1A1MEN1TP53SMN1; SMN2 | |
| SCHEMBL8042780 | 0.85 | KDM4E (0.43) | KMT2AALDH1A1MEN1TP53SMN1; SMN2 | |
| SCHEMBL8047172 | 0.85 | SMN1; SMN2 (0.44) | KMT2AALDH1A1MEN1TP53SMN1; SMN2 | |
| SCHEMBL8043141 | 0.83 | SMN1; SMN2 (0.42) | KMT2AALDH1A1MEN1TP53SMN1; SMN2 | |
| SCHEMBL8052354 | 0.83 | L3MBTL1 (0.46) | KMT2AALDH1A1MEN1LMNAHSD17B10 | |
| SCHEMBL8043201 | 0.82 | PDK1 (0.52) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA | |
| SCHEMBL8041984 | 0.82 | SMN1; SMN2 (0.51) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA | |
| SCHEMBL8044433 | 0.81 | KMT2A (0.47) | KMT2AALDH1A1MEN1TP53SMN1; SMN2 | |
| SCHEMBL8042716 | 0.80 | ALDH1A1 (0.52) | KMT2AALDH1A1MEN1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |