Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044857 | 0.86 | KDM4E (0.53) | KDM4ETSHRMEN1KMT2AHDAC6 | |
| SCHEMBL8042794 | 0.82 | TSHR (0.59) | KDM4ETSHRMEN1KMT2ACYP3A4 | |
| SCHEMBL8044904 | 0.82 | TSHR (0.41) | KDM4ETSHRMEN1KMT2AHDAC6 | |
| SCHEMBL8046525 | 0.82 | TSHR (0.49) | KDM4ETSHRMEN1KMT2AHDAC6 | |
| SCHEMBL8048578 | 0.81 | TSHR (0.49) | KDM4ETSHRMEN1KMT2ACYP3A4 | |
| SCHEMBL8042595 | 0.81 | RAB9A (0.47) | KDM4ETSHRMEN1KMT2ACYP3A4 | |
| SCHEMBL8045340 | 0.80 | KDM4E (0.63) | KDM4ETSHRMEN1KMT2AHDAC6 | |
| SCHEMBL8047161 | 0.80 | ALDH1A1 (0.69) | KDM4ETSHRMEN1KMT2AHDAC6 | |
| SCHEMBL8042827 | 0.80 | TSHR (0.47) | KDM4ETSHRMEN1KMT2AHDAC6 | |
| SCHEMBL8043015 | 0.80 | NPSR1 (0.51) | KDM4ETSHRMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |