Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 7/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048321 | 0.87 | KDM4E (0.41) | KDM4ENPSR1GAAAPOBEC3GL3MBTL1 | |
| SCHEMBL8043226 | 0.82 | ALDH1A1 (0.48) | KDM4ENPSR1GAAAPOBEC3GL3MBTL1 | |
| SCHEMBL8050181 | 0.82 | KDM4E (0.46) | KDM4ENPSR1GAAAPOBEC3GL3MBTL1 | |
| SCHEMBL8044125 | 0.81 | KDM4E (0.47) | KDM4ENPSR1GAAAPOBEC3GL3MBTL1 | |
| SCHEMBL8045239 | 0.79 | NPSR1 (0.41) | KDM4ENPSR1GAAAPOBEC3GL3MBTL1 | |
| SCHEMBL8049864 | 0.79 | KDM4E (0.44) | KDM4ENPSR1GAAAPOBEC3GL3MBTL1 | |
| SCHEMBL8044988 | 0.79 | KDM4E (0.58) | KDM4EL3MBTL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL8043257 | 0.78 | KDM4E (0.43) | KDM4ENPSR1GAAAPOBEC3GL3MBTL1 | |
| SCHEMBL8042794 | 0.78 | TSHR (0.59) | KDM4ENPSR1ALDH1A1POLBHSD17B10 | |
| SCHEMBL8048578 | 0.78 | TSHR (0.49) | KDM4ENPSR1ALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |