Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042914 | 0.81 | LMNA (0.43) | TP53HSD17B10ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL8042172 | 0.81 | ALDH1A1 (0.38) | TP53HSD17B10JAK2TLR9ALDH1A1 | |
| SCHEMBL8050933 | 0.81 | LMNA (0.40) | TP53HSD17B10JAK2TLR9ALDH1A1 | |
| SCHEMBL8047144 | 0.81 | HSD17B10 (0.40) | TP53HSD17B10JAK2TLR9ALDH1A1 | |
| SCHEMBL8044691 | 0.78 | HSD17B10 (0.36) | TP53HSD17B10JAK2TLR9ALDH1A1 | |
| SCHEMBL8044908 | 0.78 | TP53 (0.35) | TP53HSD17B10JAK2TLR9ALDH1A1 | |
| SCHEMBL8715721 | 0.78 | ALDH1A1 (0.41) | TP53HSD17B10JAK2TLR9ALDH1A1 | |
| SCHEMBL8047860 | 0.78 | TP53 (0.38) | TP53HSD17B10JAK2TLR9ALDH1A1 | |
| SCHEMBL8043601 | 0.77 | ALDH1A1 (0.37) | TP53HSD17B10JAK2TLR9ALDH1A1 | |
| SCHEMBL8043071 | 0.77 | TP53 (0.35) | TP53HSD17B10JAK2TLR9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |