Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045872 | 0.83 | FBP1 (0.40) | TP53HSD17B10JAK2TLR9SMN1; SMN2 | |
| SCHEMBL8043970 | 0.79 | KMT2A (0.43) | TP53HSD17B10SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL8048242 | 0.77 | HSD17B10 (0.37) | TP53HSD17B10SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL8044748 | 0.77 | TP53 (0.42) | TP53HSD17B10JAK2TLR9SMN1; SMN2 | |
| SCHEMBL8045937 | 0.77 | TP53 (0.38) | TP53HSD17B10JAK2TLR9SMN1; SMN2 | |
| SCHEMBL8044672 | 0.77 | TP53 (0.32) | TP53HSD17B10JAK2TLR9SMN1; SMN2 | |
| SCHEMBL8043601 | 0.76 | ALDH1A1 (0.37) | TP53HSD17B10JAK2TLR9SMN1; SMN2 | |
| SCHEMBL8043945 | 0.76 | ALDH1A1 (0.57) | TP53HSD17B10SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8044132 | 0.75 | TP53 (0.37) | TP53HSD17B10JAK2TLR9SMN1; SMN2 | |
| SCHEMBL8050031 | 0.75 | ALDH1A1 (0.31) | TP53HSD17B10SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |